Search results for " Fc"

Early entry events in Echovirus 30 infection

2020

Echovirus 30 (E30), a member of the enterovirus B species, is a major cause of viral meningitis, targeting children and adults alike. While it is a frequently isolated enterovirus and the cause of several outbreaks all over the world, surprisingly little is known regarding its entry and replication strategy within cells. In this study, we used E30 strain Bastianni (E30B) generated from an infectious cDNA clone in order to study early entry events during infection in human RD cells. E30B required the newly discovered Fc echovirus receptor (FcRn) for successful infection, but not the coxsackievirus and adenovirus receptor (CAR) or decay-accelerating factor (DAF), although an interaction with …

Polyaspartamide based microparticles for Tobramycin delivery to the lung in FC therapy

2015

Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.

2005

Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system. Here we show that pp65, the main tegument protein of human cytomegalovirus, inhibited natural killer cell cytotoxicity by an interaction with the activating receptor NKp30. This interaction was direct and specific, leading to dissociation of the linked CD3zeta from NKp30 and, consequently, to reduced killing. Thus, pp65 is a ligand for the NKp30 receptor and demonstrates a unique mechanism by which an intracellular viral protein causes general suppression of natural killer cell cytotoxicity by specific interaction w…

Riga Football Club mārketinga komunikāciju analīze.

2020

Bakalaura darba tēma – Riga Football Club mārketinga komunikāciju analīze. Bakalaura tēma ir aktuāla, jo Latvijas futbolu klubi cīnās par savu un savu spēlētāju, kā arī piedāvāto produktu atpazīstamību, līdz ar to ir nepieciešams izmantot mārketinga komunikācijas, tādā veidā piesaistot sev papildus līdzjutējus un sponsorus, kā arī spēlētājiem ir lielāka motivācija spēlēt klubā, kurs ir populārs un zināms. Bakalaura darba pētāmā problēma ir Riga Football Club mārketinga komunikāciju analīze. No pētāmās problēmas izriet bakalaura darba mērķis, kas ir, pamatojoties uz teorētisko informāciju, veikto respondentu aptauju un pieejamiem datiem par klubu, veikt Riga Football Club mārketinga komunikā…

Leveraging Users' Likes in a Video Streaming P2P Platform

2014

This paper investigates how a p2p television platform can take advantage of the presence of frequent channel viewers to grant them a more satisfying service than to less regular spectators. The idea we explore is to learn beforehand about the users' interests, in order to cluster them in groups that display different behaviors; then, the neighborhood creation strategy and video chunk scheduling algorithm of the overlay is altered, with the aim of serving frequent spectators in a privileged manner, providing them with a faster access to the selected channel without overly penalizing less habitual customers. An analytical model is developed, to capture the difference in startup delay that the…

You'll never walk alone : tutkimus suomalaisista Everton-faneista

1999

ChiLab4It system in the QA4FAQ competition

2017

ChiLab4It is the Question Answering system (QA) for Frequently Asked Questions (FAQ) developed by the Computer-Human Interaction Laboratory (ChiLab) at the University of Palermo for participating to the QA4FAQ task at EVALITA 2016 competition. The system is the versioning of the QuASIt framework developed by the same authors, which has been customized to address the particular task. This technical report describes the strategies that have been imported from QuASIt for implementing ChiLab4It, the actual system implementation, and the comparative evaluations with the results of the other participant tools, as provided by the organizers of the task. ChiLab4It was the only system whose score re…

Erectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the REWIND placebo-controlled randomised trial.

2021

Digital

Forecasts on the development of hydrogen refuelling infrastructures in Portugal

2021

In Portugal, the transition to new forms of mobility has begun in recent years, but there are still obstacles to overcome. Currently, hybrid vehicles (PHEVs) are the most widespread and accepted by the community and that is probably due to range anxiety, having in fact the possibility of double charging (both through the thermal engine and the electric battery). Furthermore, it must be considered that in addition to electric vehicles, another valid alternative to mobility in the near future is the hydrogen vehicles one. These appear to be even more sustainable from the point of view of air emissions, but on the other hand the costs for the production of hydrogen are still too high. Then, th…

Daratumumab for the Treatment of Multiple Myeloma

2018

This mini-review will summarize the present state of development of the CD38 antibody daratumumab for the treatment of multiple myeloma.